Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams.

Just two games into the season, the Rams (0-2) are approaching desperate times as they prepare to face the San Francisco ...

The San Francisco 49ers officially have a significant injury problem on their hands. Running back Christian McCaffrey is out ...

SFGATE columnist Drew Magary still is beaming from the San Francisco 49ers' loss to his favorite team, the Minnesota Vikings.

Here's where the San Francisco 49ers and the rest of the NFL stand in the latest power rankings heading into Week 3.

The last time these 49ers won a game in Minnesota was all the way back in 1992. To put that into perspective, Steve Young and ...

The 49ers and Vikings had two of the Top 5 most impressive wins during Week 1 of the NFL season, but only one can come away 2 ...

Fred Warner was one of the 49ers' lone bright spots on defense. The unit struggled especially mightily on third down against ...

Not only will San Francisco 49ers star running back Christian McCaffrey miss another game, but he's in jeopardy of being ...

The Cardinals' Drew Petzing unlocked Marvin Harrison Jr., and Matt LaFleur successfully steered the Packers without Jordan ...

The San Francisco 49ers didn't skip a beat in their Week 1 win against the New York Jets on Monday night. Now, they head to ...

Running back Christian McCaffrey will miss his second game in a row Sunday when the San Francisco 49ers take on the Minnesota ...